Late to this party.
Been to most/all of the craft breweries in Houston. St. Arnolds, Buffalo Bayou, Karbach and 8th Wonder. St. Arnold's is nice, but I like Karbach's offerings most of all.
I'm rarely driving when I'm down there to visit friends but there are some excellent beer bars.
Flying Saucer (downtown), Hay Merchant, Moon Tower, Ginger Man, Petrol Station just to name a few.